Trazodone was a more effective and less-costly than quetiapine as an alternative sleeping pill.
Trazodone prolonged sleep time and decreased the number of nighttime awakenings better than quetiapine.
The size of the initial loading dose is influenced by: If the initial 3 to 4 loading doses are ineffective the loading dose can be increased by 25 to 50 % after an appropriate assessment of the patient.
The increased loading dose can be repeated as many times as required, titrated against the patient's pain level and the side effects of the opioid.
Many studies have demonstrated a five fold variability in the quantity of intravenous opioid required to produce equivalent analgesia after surgery.
The loading dose should be repeated every 5 -10 minutes (5 minutes for fentanyl) so that the effect of the dose is felt before the next dose is administered.
During the first week, both trazodone and zolpidem were similar in improving sleep latency, total sleep time and sleep quality, and decreasing wakefulness after sleep onset.Currently, trazodone is the second most commonly prescribed treatment for insomnia.Trazodone is often used as a hypnotic for sleep difficulties even in non-depressed insomniacs.Trazodone: "off-label" sleeping pill Trazodone hcl is a sedating antidepressant with significant anxiolytic and sedative activity.In practice it is widely used off-label to treat insomnia.