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The term hypochromia refers to RBC populations in which MCH is The RBC indices can help indicate the mechanism of anemia and narrow the number of possible causes.

Microcytic indices occur with altered heme or globin synthesis.

We thank Masimo Corporation for providing the probes used in this study; however, they did not participate in the study design, analysis and interpretation of the data, or the preparation or approval of the manuscript.

We also thank the respiratory therapists, neonatologists, neonatal fellows and the staff of LAC USC Neonatal Intensive Care Unit for their cooperation with the study.

Cancer, rheumatic disorders, and chronic inflammatory disorders can suppress bone marrow activity or enlarge the spleen.

The symptoms of anemia are neither sensitive nor specific and do not help differentiate between types of anemias.

and number of platelets, plus mean corpuscular volume (MCV, a measure of RBC volume).

Hemorrhage, before iron deficiency develops, usually results in normocytic and normochromic anemia unless the number of large reticulocytes is excessive.

Signs of underlying disorders are often more diagnostically accurate than are signs of anemia. Hemorrhagic shock (eg, hypotension, tachycardia, pallor, tachypnea, diaphoresis, confusion) may result from acute bleeding. Splenomegaly may occur with hemolysis, hemoglobinopathy, connective tissue disease, myeloproliferative disorder, infection, or cancer.

Peripheral neuropathy suggests vitamin B12 deficiency. Abdominal distention in a patient with blunt trauma suggests acute hemorrhage.

Symptoms such as weakness, fatigue, drowsiness, angina, syncope, and dyspnea on exertion can indicate anemia.

Vertigo, headache, pulsatile tinnitus, amenorrhea, loss of libido, and GI complaints may also occur.

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